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Related Concept Videos

The Blood-brain Barrier00:49

The Blood-brain Barrier

Overview

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Articles linked to this work by shared authors, journal, and citation graph.

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Related Experiment Video

Updated: Jun 2, 2026

Isolation of Primary Murine Brain Microvascular Endothelial Cells
08:14

Isolation of Primary Murine Brain Microvascular Endothelial Cells

Published on: November 14, 2014

Brain microvascular endothelial cells: Beyond a barrier.

Jiahao Ou1,2, Ketian Hou1,2, Yihan Fu1,2

  • 1Department of Neonatology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
|June 1, 2026
PubMed
Summary

The blood-brain barrier (BBB) is not passive but actively regulates brain immunity via brain microvascular endothelial cells (BMECs). Understanding BMEC immunoregulatory functions offers new therapeutic targets for neurological diseases.

Keywords:
BBB permeabilityBlood–brain barrierbrain microvascular endothelial cellscentral nervous system disordersneuroimmune regulationneuroinflammation

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Generation of an Immortalized Murine Brain Microvascular Endothelial Cell Line as an In Vitro Blood Brain Barrier Model
09:36

Generation of an Immortalized Murine Brain Microvascular Endothelial Cell Line as an In Vitro Blood Brain Barrier Model

Published on: August 29, 2012

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Last Updated: Jun 2, 2026

Isolation of Primary Murine Brain Microvascular Endothelial Cells
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Published on: November 14, 2014

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Generation of an Immortalized Murine Brain Microvascular Endothelial Cell Line as an In Vitro Blood Brain Barrier Model
09:36

Generation of an Immortalized Murine Brain Microvascular Endothelial Cell Line as an In Vitro Blood Brain Barrier Model

Published on: August 29, 2012

Area of Science:

  • Neuroscience
  • Immunology
  • Cell Biology

Background:

  • The blood-brain barrier (BBB) was traditionally viewed as a passive filter.
  • Brain microvascular endothelial cells (BMECs) form the structural basis of the BBB.
  • Emerging evidence suggests BMECs have active roles in brain immunity.

Purpose of the Study:

  • To re-evaluate the role of BMECs within the neurovascular unit.
  • To highlight BMECs as dynamic immunoregulatory sentinels.
  • To explore BMEC involvement in central nervous system disorders.

Main Methods:

  • Review of current literature on BBB and BMEC function.
  • Analysis of signaling pathways (e.g., Wnt/β-catenin, NF-κB) in BMECs.
  • Examination of BMEC interactions with immune cells and inflammatory signals.

Main Results:

  • BMECs actively sense and respond to inflammatory and pathogenic signals.
  • BMECs integrate signaling pathways to balance barrier integrity and immune defense.
  • Dysfunctional BMECs contribute to neuroinflammation and barrier breakdown in CNS disorders like stroke, Alzheimer's disease, and multiple sclerosis.

Conclusions:

  • BMECs are active participants in brain immunity, not just passive structural components.
  • Targeting BMEC immunoregulatory functions presents novel therapeutic strategies for neurological diseases.
  • Further research is needed to address endothelial heterogeneity and develop precise interventions.