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Updated: Jun 2, 2026

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
08:46

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Published on: December 9, 2015

Metal-Based Therapeutic Approaches for Overcoming Cancer Drug Resistance: Mechanisms, Drug Delivery Strategies, and

Kirill V Chernov1, Artemii M Savin1, Daria E Otvodnikova1

  • 1Center for Molecular and Biological Sciences, National Research University ITMO, Saint-Petersburg, Russia.

Oncology Research
|June 1, 2026
PubMed

Insights

Metal-based therapeutics offer unique anti-cancer properties to overcome drug resistance, combining targeted and conventional therapy benefits. Further development is needed to increase their clinical application against cancer.

Area of Science:

  • Oncology
  • Medicinal Chemistry
  • Materials Science

Background:

  • Drug resistance is a major challenge in cancer therapy, limiting the effectiveness of current treatments.
  • Targeted therapies have limitations in versatility, and conventional therapies often cause severe side effects.
  • There is a need for novel therapeutic strategies that combine the advantages of both approaches.

Purpose of the Study:

  • To review the potential of metal-based therapeutics in overcoming cancer drug resistance.
  • To highlight the unique properties of metal compounds that can be leveraged for cancer treatment.
  • To discuss current strategies and challenges in the development of metal-based anti-cancer drugs.

Main Methods:

  • Literature review of metal-based compounds in oncology.
  • Analysis of physico-chemical properties and biological activities of metal therapeutics.
  • Discussion of modern strategies for metal-based cancer therapy, diagnostics, and drug delivery.

Main Results:

  • Metal-based therapeutics exhibit unique activities, including precise targeting, induction of non-apoptotic cell death, and disruption of cancer signaling pathways.
  • Metals' unique properties enable versatile therapeutic applications in both normal and cancer cells.
  • Despite advantages, the number of approved metal-based drugs remains limited.

Conclusions:

  • Metal-based therapeutics are promising candidates for combating cancer drug resistance due to their versatile mechanisms of action.
  • Further research and development are crucial to overcome hurdles and increase the clinical translation of metal-based drugs.
  • Optimizing therapy, diagnostics, and drug delivery strategies will enhance the efficacy of metal-based agents in oncology.
Keywords:
Drug resistancedrug conjugatesmetal nanoparticles (MNPs)metal-based formulationsoxidative therapyreactive oxygen species

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