Related Experiment Video
Updated: Jun 2, 2026
09:35
Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain
Published on: May 10, 2017
Trigeminal Trophic Syndrome: A Case Report and Literature Review
Han-Sang Song1, Il-Hwan Kim2, Hi-Jin You1,3
1Department of Plastic and Reconstructive Surgery, Korea University Ansan Hospital, Ansan, Republic of Korea.
Archives of Plastic Surgery
|June 1, 2026
Summary
Trigeminal trophic syndrome (TTS) can mimic cancer, presenting as facial ulcers. Differentiating TTS from malignancy is crucial, especially in older adults with neurological issues, to avoid unnecessary treatments.
Area of Science:
- Neurocutaneous disorders
- Dermatology
- Neurology
Background:
- Trigeminal trophic syndrome (TTS) is a rare condition characterized by facial numbness, altered sensations, and nasal ulceration.
- Distinguishing TTS from facial malignancies can be challenging due to overlapping clinical presentations.
Purpose of the Study:
- To highlight the importance of differentiating Trigeminal trophic syndrome (TTS) from squamous cell carcinoma in an elderly patient.
- To emphasize the diagnostic challenges and necessary investigations for TTS.
Main Methods:
- Case report of an 86-year-old woman with trigeminal neuralgia.
- Combined histopathologic, radiologic, and clinical evaluation of a nasal ulcerated lesion.
- Differential diagnosis between TTS and malignancy.
Main Results:
- Initial biopsy suggested squamous cell carcinoma, but further investigation confirmed Trigeminal trophic syndrome (TTS).
- The patient's presentation included trigeminal anesthesia, facial paresthesia, and a nasal ulcer.
Conclusions:
- Accurate diagnosis of Trigeminal trophic syndrome (TTS) is essential to prevent misdiagnosis as cancer.
- Early recognition and appropriate management of TTS can avoid invasive procedures and improve patient outcomes, particularly in elderly individuals with neurological comorbidities.
