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Elevated Systemic Inflammatory Response Index Is Associated With Increased Risk of Severe Acute Pancreatitis: A
Sathish Narayanaswamy1, Anastasia Postoev2, Zartasha3
1Neurosciences, University Hospitals North Midlands, Stoke-on-Trent, GBR.
Cureus
|June 1, 2026
Summary
The Systemic Inflammatory Response Index (SIRI) may help predict severe acute pancreatitis (AP). Higher SIRI levels at admission correlate with increased risk and severity of AP, warranting further investigation.
Area of Science:
- Gastroenterology and Hepatology
- Critical Care Medicine
- Biomarker Research
Background:
- Acute pancreatitis (AP) is a frequent gastrointestinal emergency with a high risk of progression to severe acute pancreatitis (SAP).
- SAP is associated with significant morbidity and mortality, necessitating improved prognostic tools.
- Early identification of patients at risk for SAP is crucial for timely intervention and improved outcomes.
Purpose of the Study:
- To conduct a meta-analysis assessing the association between the Systemic Inflammatory Response Index (SIRI) and the severity of acute pancreatitis (AP).
- To evaluate whether SIRI levels can serve as a predictive marker for the progression to severe acute pancreatitis.
Main Methods:
- A systematic literature search was performed across major databases (PubMed, Scopus, Web of Science, Embase, Cochrane Library, Google Scholar) up to February 2026.
- Nine eligible studies providing quantitative data on SIRI and AP severity in adult populations were included in the meta-analysis.
- Random-effects modeling was employed using RevMan software to synthesize data, with methodological quality assessed by the Newcastle-Ottawa Scale.
Main Results:
- Higher SIRI values were significantly correlated with an increased likelihood of severe acute pancreatitis (OR: 1.99; 95% CI: 1.46-2.72).
- Patients with severe AP exhibited significantly higher mean SIRI levels compared to those with mild AP (MD: 4.30; 95% CI: 0.41-8.19).
- Substantial heterogeneity was observed among the included studies (I² > 89%).
Conclusions:
- Elevated SIRI at admission is associated with an increased risk and severity of acute pancreatitis.
- These findings are preliminary and hypothesis-generating, suggesting SIRI as a potential prognostic biomarker.
- Further large-scale prospective studies are required to validate SIRI's clinical utility and establish optimal cut-off values.
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