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Atypical Ulcerated Cutaneous Presentation of Diffuse Large B-Cell Lymphoma: A Case Report
Paula Nogueira1, Isabel V Rodrigues1, Pedro Reboredo1
1Internal Medicine, Unidade Local de Saúde do Algarve - Hospital de Faro, Faro, PRT.
Cureus
|June 1, 2026
Summary
This case report details a rare instance of cutaneous diffuse large B-cell lymphoma (DLBCL) presenting as a rapidly progressing shoulder mass. Early biopsy is crucial for diagnosing uncommon extranodal lymphoma presentations to improve patient outcomes.
Area of Science:
- Oncology
- Dermatology
- Hematology
Background:
- Diffuse large B-cell lymphoma (DLBCL) is a common aggressive non-Hodgkin lymphoma.
- DLBCL typically involves lymph nodes, with cutaneous involvement being rare.
- Cutaneous DLBCL can mimic other skin conditions, potentially delaying diagnosis and treatment.