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Tooth Discoloration After Regenerative Endodontic Therapy in Immature Permanent Teeth: A Systematic Review
Ethar Mahmoud1, Safaa Beshir Omer Beshir1, Niroz T Wadhaj2
1Faculty of Dentistry, University of Khartoum, Khartoum, SDN.
Cureus
|June 1, 2026
Summary
Tooth discoloration after regenerative endodontic therapy is common. Careful selection of barrier materials and meticulous pulp chamber cleaning can prevent this esthetic complication in immature teeth.
Area of Science:
- Dentistry
- Regenerative Endodontics
- Esthetic Dentistry
Background:
- Tooth discoloration is a frequent esthetic issue after regenerative endodontic therapy (RET) in immature permanent teeth.
- Understanding the causes and prevention of discoloration is crucial for successful RET outcomes.
Purpose of the Study:
- To systematically review the occurrence of tooth discoloration post-RET.
- To identify factors contributing to discoloration within treatment protocols.
- To synthesize strategies for preventing post-RET discoloration.
Main Methods:
- A comprehensive literature search was performed to identify eligible clinical studies.
- Studies were screened and assessed for full-text eligibility.
- Due to heterogeneity, quantitative meta-analysis was not feasible.
Main Results:
- Reported rates of tooth discoloration varied significantly across studies.
- Higher discoloration incidence was noted in trauma-related cases compared to material-comparison studies.
- Coronal barrier material choice and management of the access cavity/pulp chamber were key contributing factors.
Conclusions:
- Tooth discoloration can occur despite favorable clinical and radiographic results of RET.
- Preventive strategies should focus on using less-staining materials.
- Technique-sensitive decontamination of the pulp chamber is vital for minimizing esthetic compromise.
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