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Related Concept Videos

Pharmacovigilance01:19

Pharmacovigilance

Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
Local Anesthetics: Adverse Effects01:12

Local Anesthetics: Adverse Effects

While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies. Common...
Vaccinations01:51

Vaccinations

Overview
Vaccines01:21

Vaccines

Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the type of...
Pharmaceutical Poisoning: Potential Scenarios01:26

Pharmaceutical Poisoning: Potential Scenarios

Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...

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Related Experiment Video

Updated: Jun 2, 2026

Intracranial Injection of Adeno-associated Viral Vectors
08:47

Intracranial Injection of Adeno-associated Viral Vectors

Published on: November 17, 2010

Serious Adverse Events Following COVID-19 Vaccination: A Descriptive Case Series From a Rural Healthcare System.

Rajesh M Prabhu1, Andrew C Chiu2, Stephen C Waring3

  • 1Infectious Diseases, Essentia Health, Duluth, USA.

Cureus
|June 1, 2026
PubMed
Summary
This summary is machine-generated.

This case series reports on 18 patients experiencing adverse events following immunization (AEFI) after COVID-19 vaccination. The study details various clinical presentations, including cardiovascular and neurological conditions, to aid clinicians in diagnosis.

Keywords:
adverse event following immunizationburning mouth syndromedemyelinating syndromeerythromelalgiamoderna covid-19 vaccinemultisystem inflammatory syndromemyocarditispfizer-biontech covid-19 vaccinestaphylococcus aureus

Related Experiment Videos

Last Updated: Jun 2, 2026

Intracranial Injection of Adeno-associated Viral Vectors
08:47

Intracranial Injection of Adeno-associated Viral Vectors

Published on: November 17, 2010

Area of Science:

  • Immunology
  • Vaccinology
  • Clinical Medicine

Background:

  • COVID-19 mRNA vaccines received Emergency Use Authorization in December 2020.
  • Clinicians observed serious adverse events following immunization (AEFI) with COVID-19 vaccines.
  • This study aims to document the clinical course of patients experiencing AEFI.

Purpose of the Study:

  • To report the clinical course of patients with adverse events following COVID-19 vaccination.
  • To assist clinicians in considering AEFI when other explanations are absent.
  • To highlight the diversity of potential adverse events for further investigation.

Main Methods:

  • A descriptive case series of 18 patients (ages 18-82) identified prospectively between January and December 2021.
  • Cases with alternative explanations for symptoms were excluded.
  • No statistical analysis was performed; focus on clinical presentation and course.

Main Results:

  • Eighteen patients (9 male, 9 female) presented with various AEFI.
  • Affected organ systems included cardiovascular, nervous, immune/hematologic, skin, gastrointestinal, pulmonary, and infection.
  • Specific conditions observed: myocarditis, encephalitis, Bell's palsy, immune thrombocytopenia, and others.

Conclusions:

  • A range of adverse events following COVID-19 vaccination was observed, including myocarditis, encephalitis, and immune thrombocytopenia.
  • This case series aids clinicians in diagnosing AEFI when other causes are ruled out.
  • The findings do not imply causality but encourage further research into risks and relationships.