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SARS-CoV-2 and reproductive system: a scientometric study.
Linghan Zhang1, Minkai Wang2, Huijuan Zhang3
1Department of Reproductive Medicine, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Frontiers in Reproductive Health
|June 1, 2026
Summary
The scientific literature on SARS-CoV-2 and the genital system shows a declining trend, with early themes related to reproductive health remaining underdeveloped. Further research is needed to understand the long-term impact of the virus on reproductive health.
Area of Science:
- Virology
- Reproductive Medicine
- Public Health
Background:
- The interaction between SARS-CoV-2 and human cells, particularly long-term effects on the reproductive system, is poorly understood.
- Growing evidence, including Long COVID cases, highlights the need for public health concern regarding these interactions.
Purpose of the Study:
- To analyze the scientific development status of research on SARS-CoV-2 and the human genital system.
- To identify key research hotspots, thematic trends, and major issues in this field through scientometric analysis.
Main Methods:
- A comprehensive scientometric analysis was performed on literature published between 2020 and 2025.
- Data was retrieved from three major databases: Web of Science Core Collection, Scopus, and PubMed.
- Bibliometrix/BiblioShiny tools were utilized for the analysis.
Main Results:
- A total of 2,354 publications were analyzed, showing a declining trend in annual production since 2022.
- China and the USA were the most productive countries, while emerging trends include etiology, antigen presentation, and sperm viability.
- Research collaborations were concentrated among a few countries, with limited involvement from African, Latin American, and Asian nations.
Conclusions:
- The study provides insights into research strategies, public health resource management, and scientific collaborations.
- Novel viewpoints are presented, emphasizing the need for attention to the underdeveloped themes related to SARS-CoV-2's impact on the reproductive system.
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