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Updated: Jun 2, 2026
05:39
Non-Intubated Video-Assisted Thoracoscopic Surgery
Published on: May 26, 2023
Oliceridine effectively attenuates fentanyl-induced cough during general anesthesia induction
Ru-Yi Xing1, Wen-Yi Gong2, Chen-Guang Li3
1Department of Anesthesiology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Frontiers in Medicine
|June 1, 2026
Summary
Oliceridine effectively prevented fentanyl-induced cough (FIC) in surgical patients. This prophylactic approach demonstrated a safe peri-induction profile, reducing cough incidence without significant adverse events.
Area of Science:
- Anesthesiology
- Pharmacology
Background:
- Fentanyl-induced cough (FIC) is a frequent complication during anesthesia induction.
- Limited evidence exists on oliceridine's efficacy in preventing FIC.
Purpose of the Study:
- To evaluate the prophylactic effect of oliceridine against FIC.
- To assess the safety profile of oliceridine during anesthetic induction.
Main Methods:
- A randomized trial involving 168 adult patients (ASA physical status I-III).
- Patients received either 2 mg oliceridine (OF group) or normal saline (SF group) before fentanyl.
- Primary outcome: incidence of cough within 1 minute post-fentanyl.
Main Results:
- No patients in the oliceridine group experienced FIC versus 58.33% in the saline group (p < 0.001).
- Cough severity in the saline group ranged from mild to severe.
- No significant changes in vital signs or increased adverse events were observed in the oliceridine group.
Conclusions:
- Pretreatment with 2 mg oliceridine is effective in reducing FIC incidence.
- Oliceridine offers a safe approach for anesthetic induction with minimal additional risks.
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