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MAPSeg: self-supervised colorectal polyp segmentation via memory-augmented framework and synthetic polyp simulation.

Claudia Delprete1, Domenico Buongiorno1, Roberto Maria Scardigno1

  • 1Department of Electrical and Information Engineering, Polytechnic University of Bari, Bari, Italy.

Frontiers in Digital Health
|June 1, 2026
PubMed
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MAPSeg, a novel self-supervised framework, achieves accurate colorectal polyp segmentation without manual annotations. This method, utilizing synthetic data and anomaly detection, significantly reduces annotation dependency for clinical applications.

Area of Science:

  • Medical Imaging
  • Artificial Intelligence
  • Gastroenterology

Background:

  • Colorectal cancer often develops from polyps, necessitating early detection via colonoscopy.
  • Supervised automatic polyp segmentation shows promise but requires extensive annotated datasets, limiting clinical use.

Purpose of the Study:

  • To introduce MAPSeg (Memory-Augmented Polyp Segmentation), a fully self-supervised framework for annotation-free colorectal polyp segmentation.
  • To address the limitations of supervised methods by developing an unsupervised approach.

Main Methods:

  • MAPSeg employs an anomaly detection paradigm trained on healthy colon images.
  • It integrates SIMPO (Simulation of Polyps) for realistic synthetic polyp generation.
  • A memory-augmented encoder models normal tissue structures.
Keywords:
anomaly detectionmedical image analysismemory-augmented networkspolyp segmentationsynthetic data generationunsupervised learning

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Main Results:

  • MAPSeg significantly outperforms existing unsupervised methods on the Hyper-Kvasir dataset (23% IoU, 12% DICE).
  • The framework demonstrates strong generalization across diverse out-of-distribution benchmarks.
  • High segmentation accuracy is maintained without manual annotations.

Conclusions:

  • MAPSeg, enhanced by SIMPO, offers a practical solution for unsupervised polyp segmentation.
  • The approach substantially reduces reliance on manual annotations while ensuring high accuracy.
  • This facilitates more accessible and efficient colorectal polyp detection.