Related Experiment Video

Updated: Jun 2, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Reduced C3 Levels Link Dyslipidemia and Renal Involvement in Systemic Lupus Erythematosus

Shuo Cheng1,2, Yi Jiang1, Zhanheng Hu1,2

  • 1Department of Rheumatology and Immunology, The First Affiliated Hospital of Shenzhen University, Shenzhen University, Shenzhen, People's Republic of China.

Journal of Inflammation Research
|June 1, 2026
PubMed

Insights

Low complement C3 levels are linked to dyslipidemia and kidney issues in systemic lupus erythematosus (SLE) patients. Combining C3 and ESR can help predict dyslipidemia risk.

Area of Science:

  • Immunology
  • Rheumatology
  • Clinical Chemistry

Background:

  • Dyslipidemia is common in systemic lupus erythematosus (SLE) patients, particularly those with hypocomplementemia.
  • This suggests a link between immune system dysfunction and lipid metabolism in SLE.

Purpose of the Study:

  • To investigate the association between complement components and lipid profiles in SLE patients.
  • To determine the influence of these associations on organ involvement.

Main Methods:

  • 935 SLE patients were analyzed, stratified by lipid profiles.
  • Logistic regression, stratified analyses, and ROC curves were used to assess predictors of dyslipidemia and organ involvement.

Main Results:

  • 56.4% of SLE patients had dyslipidemia.
  • Lower C3 levels were independently associated with increased risk of dyslipidemia (OR=0.29) and renal involvement (OR=0.21).
  • A predictive model using C3 and ESR showed 74.7% specificity for dyslipidemia.

Conclusions:

  • Reduced C3 levels are a significant risk factor for dyslipidemia and renal involvement in SLE.
  • The combination of C3 and ESR levels improves dyslipidemia identification in SLE patients.
Abstract

Keywords:
complement C3dyslipidemiaimmune dysregulationlipid metabolismsystemic lupus erythematosus

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