Related Experiment Video

Updated: Jun 2, 2026

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A Rare Case of Acromegaly and Prolactinoma in MEN4 Caused by a CDKN1B Mutation

Liu Yuke1, Wang Hongxing1, Tan Huiwen1

  • 1Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China.

AACE Endocrinology and Diabetes
|June 1, 2026
PubMed
Abstract

Insights

Multiple endocrine neoplasia type 4 (MEN4) is a rare genetic disorder caused by CDKN1B mutations. This case highlights its diverse presentation, emphasizing genetic testing for accurate diagnosis and management of endocrine tumors.

Area of Science:

  • Endocrinology
  • Genetics
  • Oncology

Background:

  • Multiple endocrine neoplasia (MEN) disorders involve tumors in endocrine glands.
  • MEN4, a rare subtype, is caused by germline mutations in the CDKN1B gene.
  • Clinical characteristics of MEN4 are not well understood due to limited cases.
Keywords:
CDKN1Bacromegalyhyperparathyroidismhyperprolactinemiamultiple endocrine neoplasiapituitary neuroendocrine tumors

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