Related Experiment Video
Updated: Jun 2, 2026

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
Published on: April 3, 2017
Synergistic Impact of Obesity and PCOS on Immune Dysregulation: A Review of Systemic and Local Inflammatory Profiles
1Reproductive Medical Center, Lianyungang Maternal and Child Health Hospital, Lianyungang, Jiangsu, People's Republic of China.
Abstract:
Polycystic ovary syndrome (PCOS) exacerbated by obesity represents a complex intersection of endocrine and immune dysregulation, significantly impairing reproductive and metabolic health. This characterizes the immune-inflammatory landscape of the phenotype and evaluate the clinical utility of the Systemic Immune-Inflammation Index (SII) in assessing inflammatory status and predicting long-term complications. Furthermore, analyze how systemic chronic inflammation alters the ovarian microenvironment-specifically impairing follicular development, granulosa cell function, and oocyte quality-through the recruitment of macrophages, T-cell activation, and the elevation of pro-inflammatory cytokines like tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6). Finally, focused on emerging diagnostic and therapeutic strategies centered on immunomodulation, offering a framework for precision clinical management.
More Related Videos
Related Concept Videos
Obesity
Dysbiosis of the Gut Microbiota
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution
Psychoneuroimmunology: Diabetes and Cancer
Irritable Bowel Syndrome I: Introduction
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...

