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Updated: Jun 2, 2026

Characterizing RNA Modifications in Single Neurons Using Mass Spectrometry
Published on: April 21, 2022
Interaction between N6-methyladenosine (m6A) modification and toxicant-related neurodegeneration: From neural
Zhou She1,2, Peng Huang1,2, Senlin Luo1,2
1Department of Pediatrics, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.
Abstract:
N6-methyladenosine (m6A) modification is a crucial epigenetic mechanism that is widely expressed across various tissues and biological systems. It regulates gene expression by influencing the stability and translation of messenger RNAs, thereby affecting key physiological processes such as cell division, proliferation, and apoptosis. m6A modification plays an essential role in maintaining normal physiological functions and in the pathogenesis of a variety of diseases. Recent studies have highlighted the involvement of m6A in the development of the nervous system and its contribution to neurodegenerative diseases, including Alzheimer's and Parkinson's disease. However, research on the involvement of m6A in nervous system disorders induced by toxic substances remains limited. This review provides an updated overview of the role of m6A in neural development, with a particular focus on exploring the potential mechanisms by which m6A contributes to toxicant-related neurodegeneration diseases.
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