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  1. Home
  3. Atf3-based Peripheral Neural Tract Tracing.
  1. Home
  3. Atf3-based Peripheral Neural Tract Tracing.

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Related Experiment Video

Laser-guided Neuronal Tracing In Brain Explants
06:40

Laser-guided Neuronal Tracing In Brain Explants

Published on: November 25, 2015

ATF3-based peripheral neural tract tracing.

Laurent Gautron1

  • 1Department of Internal Medicine and Center for Hypothalamic Research, UT Southwestern Medical Center, Dallas, TX, United States.

Frontiers in Neuroanatomy
|June 1, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

This study introduces activating transcription factor 3 (ATF3) as a novel marker for mapping peripheral nervous system neural connections. This injury-response method aids in understanding organ innervation and resolving debates on visceral pathways.

Keywords:
autonomic nervous systemaxotomytracerstranscription factorvagus nerve

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Area of Science:

  • Neuroscience
  • Peripheral Nervous System Research

Background:

  • Mapping neural connections in peripheral organs is challenging.
  • Existing retrograde tracing methods in peripheral tissues face controversy.

Purpose of the Study:

  • To present an alternative approach for identifying organ-specific innervation.
  • To utilize the neuronal injury response as a tool for neural circuit mapping.

Main Methods:

  • Discusses the use of activating transcription factor 3 (ATF3) as a molecular marker.
  • ATF3 is upregulated in neurons following axonal injury.
  • Integrates classical and injury-induced approaches.

Main Results:

  • ATF3 serves as an indirect marker for identifying organ-specific innervation.
  • The proposed framework offers a potentially more reliable method for peripheral circuit mapping.

Conclusions:

  • This injury-response based framework can help resolve debates on visceral innervation.
  • Improves the reliability of circuit-mapping strategies in the peripheral nervous system.