Marine-derived PUFAs and peptides for aging-related memory deficits: processing methods, pharmacokinetics,
Zhiyou Yang1, Wendi Deng1, Qidong Lu2
1Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Zhanjiang Municipal Key Laboratory of Marine Drugs and Nutrition for Brain Health, College of Food Science and Technology, Shenzhen Institute of Guangdong Ocean University, Guangdong Ocean University, Zhanjiang, China.
Abstract:
Cognitive decline and memory disorders are increasingly prevalent globally, especially in aging populations, imposing substantial social, emotional, and medical burdens on individuals and healthcare systems. Food-derived dietary interventions play a critical role in the prevention and management of these conditions, with marine-derived polyunsaturated fatty acids (PUFAs) and bioactive peptides emerging as promising candidates for enhancing brain health and cognitive function. This review summarizes advanced processing techniques for these bioactive substances, including physicochemical methods for the extraction and purification of PUFAs, as well as enzyme-mediated degradation of marine proteins for peptide production. It also covers their multifaceted mechanisms underlying memory enhancement, such as antioxidant, anti-apoptotic, anti-inflammatory, and cholinergic modulation, supported by preclinical animal studies and preliminary human clinical trials. Finally, existing challenges such as low bioavailability and unstandardized formulations, along with prospects including sustainable production, personalized bioactive blends, and precision nutrition, are discussed. This review first clarifies the complementary neuroprotective mechanisms of marine-derived PUFAs and peptides, and advocates for systematic exploration to translate preclinical findings into clinical applications.
More Related Videos
08:27Establishment of a Valuable Mimic of Alzheimer's Disease in Rat Animal Model by Intracerebroventricular Injection of Composited Amyloid Beta Protein
Published on: July 29, 2018
14:57Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
Published on: March 23, 2011
Related Concept Videos
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
Pharmacodynamics in Geriatric Patients: Effects of Age
Aging
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Role of Neurotransmitters in Memory
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is critical for...
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
Mitochondria
