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Updated: Jun 2, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
Systemic immune-inflammation Index and blood pressure control are independent and interactive predictors of atrial
Yuhang Wei1, Chenxi Cao1, Yunzhe Wang1
1Department of Cardiology, Key Laboratory of Cardiac Injury and Repair of Henan Province, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Background:
Atrial fibrillation (AF) recurrence remains a major limitation after radiofrequency catheter ablation (RFCA), especially in patients with hypertension. Systemic immune-inflammation index (SII) has emerged as a novel marker of systemic inflammation, yet its prognostic value in this population is unclear.
Objective:
To assess the predictive value of pre-ablation SII for AF recurrence and explore the modifying effect of blood pressure (BP) control status in hypertensive patients.
Methods:
In this retrospective cohort study, 568 hypertensive AF patients undergoing first-time RFCA were enrolled. Patients were stratified by SII quartiles and BP control status. Cox regression, ROC analysis, and restricted cubic spline modeling were used to evaluate associations with AF recurrence.
Results:
During a mean 34-month follow-up, 17.3% experienced AF recurrence. Elevated SII was independently associated with recurrence risk (HR per 100-unit increase: 1.138; P < 0.001). Patients with both high SII and poorly controlled BP had a > 4-fold increased risk (HR: 4.061). SII outperformed conventional markers and significantly improved model discrimination (C-statistic: 0.755).
Conclusion:
Pre-ablation SII is an independent and superior predictor of AF recurrence after RFCA in hypertensive patients, particularly when BP is poorly controlled. Combined assessment of SII and BP control may improve individualized risk stratification.
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