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Pancreatic Exocrine Insufficiency Is Surprisingly Common.
Integrative Medicine (Encinitas, Calif.)
|June 1, 2026
Summary
Digestive disturbances, including pancreatic exocrine insufficiency (EPI), are linked to chronic disease. Modern research validates this concept, highlighting EPI
Area of Science:
- Gastroenterology and Internal Medicine
- Digestive Health and Chronic Disease Research
Background:
- Natural health practitioners have long observed a connection between digestive issues and chronic diseases.
- Previous research identified hypochlorhydria and dysbiosis as contributors to maldigestion.
- Emerging evidence points to pancreatic exocrine insufficiency (EPI) as another significant factor in maldigestion.
Purpose of the Study:
- To explore the prevalence of pancreatic exocrine insufficiency (EPI) in the adult population.
- To discuss the diagnostic methods, common causes, and potential interventions for EPI.
- To highlight the role of EPI in digestive disturbances and its association with chronic diseases.
Main Methods:
- This editorial synthesizes current research and clinical observations regarding EPI.
- It reviews epidemiological data on the prevalence of EPI across different age groups and health statuses.
- The content examines established and emerging diagnostic approaches for identifying EPI.
Main Results:
- Pancreatic exocrine insufficiency (EPI) affects at least 20% of individuals aged 50-75 without diagnosed diseases.
- Prevalence rates are higher in individuals with existing medical conditions, particularly diabetes.
- EPI is increasingly recognized as a key contributor to maldigestion and digestive disturbances.
Conclusions:
- Pancreatic exocrine insufficiency (EPI) is a prevalent condition, often overlooked, contributing significantly to digestive problems.
- Early diagnosis and intervention for EPI are crucial for managing maldigestion and potentially mitigating chronic disease development.
- Further research into EPI's causes and effective treatments is warranted to improve patient outcomes.
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