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Published on: February 10, 2023

Knowledge, Attitude, and Practice Toward Long-Term Anticoagulation in Patients with Venous Thromboembolism: A

Zirong Liu1, Jinfeng Long1, Kai Wang2

  • 1School of Medical Imaging, Shandong Second Medical University, Weifang, Shandong, People's Republic of China.

Patient Preference and Adherence
|June 1, 2026
PubMed

Insights

Patients with venous thromboembolism (VTE) have suboptimal knowledge but positive attitudes and proactive practices regarding long-term anticoagulation therapy. Educational interventions should focus on improving knowledge and addressing patient concerns for better adherence and safety.

Area of Science:

  • Medical research
  • Patient care
  • Public health

Background:

  • Venous thromboembolism (VTE) necessitates long-term anticoagulation therapy.
  • Understanding patient knowledge, attitude, and practice (KAP) is crucial for effective management.
  • This study explores KAP related to long-term anticoagulation in VTE patients.

Purpose of the Study:

  • To assess the knowledge, attitude, and practice (KAP) levels of patients with venous thromboembolism (VTE) concerning long-term anticoagulation therapy.
  • To identify factors influencing KAP and their interrelationships.
  • To inform the development of targeted educational interventions.

Main Methods:

  • A cross-sectional study involving 389 VTE patients.
  • Data collected via a self-developed KAP questionnaire.
  • Structural equation modeling (SEM) used to analyze relationships between KAP domains and age-stratified subgroup analyses were performed.

Main Results:

  • Over half of patients (52.96%) had adequate knowledge, while 59.38% had positive attitudes and 75.84% demonstrated proactive practices.
  • Significant age-related differences were observed in KAP scores (P < 0.001 for knowledge and attitude, P = 0.047 for practice).
  • Attitude directly influenced practice (β = 0.674), and knowledge indirectly affected practice through attitude (β = 0.473).

Conclusions:

  • VTE patients exhibit suboptimal knowledge but positive attitudes and proactive practices towards long-term anticoagulation.
  • Clinical strategies should emphasize structured, attitude-focused education and individualized support.
  • Interventions should address patient concerns and behavioral barriers to enhance treatment adherence and safety.
Abstract

Keywords:
anticoagulantscross-sectional studieshealth behaviormedication adherencepatient knowledgevenous thromboembolism

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