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Updated: Jun 2, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Stress-induced rupioid psoriasis managed with ustekinumab
Gustavo Almeida-Silva1,2, Joana Antunes1,2
1Dermatology Department, Unidade Local de Saúde Santa Maria, Lisbon, Portugal.
Abstract:
We report the first case of stress-induced rupioid psoriasis, a rare and severe hyperkeratotic variant of psoriasis, arising after the sudden loss of a close relative. The patient achieved remarkable clearance with ustekinumab, highlighting the potential of interleukin (IL)-12/IL-23 blockade in this under-recognized phenotype. This case underscores the role of acute stress as a trigger, and the urgent need to better define the pathophysiology and tailored treatment of hyperkeratotic psoriasis variants.
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