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Updated: Jun 2, 2026

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
Published on: June 10, 2021
Access to Fluorene-Fused Isoquinolones Containing an Axially Chiral Element via Cascade Bi-Annulation Reaction of
Yan Zhao1, Yi-Hang Deng1, Ming-Yang Yu1
1College of Chemistry and Molecular Sciences, Henan University, Kaifeng 475004, China.
Abstract:
We report an aromatization-driven organocatalytic cascade bi-annulation of indene-dienes, offering a straightforward route to fluorene-fused isoquinolones containing an axially chiral element. By this strategy, with a chiral organocatalyst, axially chiral pyridyl-substituted derivatives were afforded in moderate to good yields (up to 97% yield, 90:10 er). Alternatively, using DMAP and sodium carbonate as bases, structurally phenyl-substituted fluorene-fused isoquinolones were synthesized in up to 99% yield. This protocol directly constructs two distinct classes of fluorene-fused isoquinolone frameworks.
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