Related Experiment Video
Updated: Jun 2, 2026
08:14
Novel Process for 3D Printing Decellularized Matrices
Published on: January 7, 2019
3D-Printed Composite Scaffolds Containing SiO2 for Bone Regeneration in In Vivo Models: A Systematic Review
Giovanna do Espirito Santo1, Marcelo Assis1,2, Homero Garcia-Motta1
1Department of Biosciences, Federal University of São Paulo (UNIFESP), Silva Jardim Street, 136, Santos, SP 11015020, Brazil.
ACS Omega
|June 1, 2026
Summary
Silica-functionalized 3D-printed scaffolds enhance bone regeneration by improving scaffold properties and promoting osteogenic signaling. These composite biomaterials show significant promise for treating bone defects.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Materials Engineering
Background:
- Bone fractures and osteoporosis pose significant health challenges, necessitating advanced bone regeneration strategies.
- Three-dimensional (3D) printed scaffolds offer a promising platform for bone tissue engineering, mimicking natural bone structure.
- Silica (SiO2) incorporation into biomaterials can enhance osteoblast activity, angiogenesis, and mineral deposition.
Purpose of the Study:
- To systematically review in vivo studies of 3D-printed composite scaffolds containing silica (SiO2) for bone defect repair.
- To evaluate the biological performance and regenerative outcomes of these SiO2-containing scaffolds.
Main Methods:
- Systematic literature search of PubMed, Scopus, Embase, and Web of Science (2005-2025).
- Focus on composite biomaterial systems with SiO2 as a bioactive component.
- Analysis of studies using in vivo bone defect models (rodent, rabbit).
Main Results:
- SiO2 modulated scaffold properties like porosity, surface topography, wettability, and degradation.
- Interconnected pores (200-600 μm), roughness, and hydrophilicity improved cell adhesion and protein adsorption.
- In vivo studies showed enhanced bone formation, modulated inflammation, and upregulated osteogenic gene expression, especially with calcium phosphates.
Conclusions:
- SiO2-functionalized 3D-printed scaffolds, particularly with calcium phosphates, show synergistic effects for bone regeneration.
- These scaffolds enhance surface bioactivity and osteogenic signaling, offering a promising strategy for bone tissue engineering.
