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Related Experiment Video

Updated: Jun 2, 2026

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
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Published on: February 7, 2021

Injectable Silk Fibroin-Puerarin Hydrogels with Tunable Supramolecular Organization as a Potential Platform for

Bruna V Quevedo1,2,3, Bianca Sabino Leocádio Antunes1,2, Saeed Safari3

  • 1Postgraduate Program in Materials Science (PPGCM), Federal University of São Carlos (UFSCar), Sorocaba, SP 18052-780, Brazil.

ACS Omega
|June 1, 2026
PubMed
Summary

Silk fibroin hydrogels incorporating puerarin (PUE) exhibit tunable properties for tissue engineering. These injectable biomaterials demonstrate cytocompatibility and promote cell migration, highlighting their potential for soft tissue applications.

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Supramolecular Chemistry

Background:

  • Injectable supramolecular hydrogels are promising for minimally invasive applications.
  • Silk fibroin (SF) and puerarin (PUE) are key components with potential synergistic effects.

Purpose of the Study:

  • To investigate the impact of varying puerarin (PUE) concentrations on silk fibroin (SF) hydrogel properties.
  • To evaluate the physicochemical and in vitro biological performance of PUE-modified SF hydrogels.

Main Methods:

  • Fabrication of SF-PUE hydrogels with PUE concentrations from 1-5%.
  • Characterization using FTIR, X-ray diffraction, SEM, TGA/DSC, and rheology.
  • In vitro cytocompatibility and cell migration assays using HDF cells.

Main Results:

  • PUE incorporation formed hydrogels via hydrogen bonding, maintaining SF crystallinity.
  • Increased PUE content reduced pore size, swelling, and enhanced mechanical stability and injectability.
  • Hydrogels exhibited excellent cytocompatibility and promoted complete wound closure within 72 hours.

Conclusions:

  • Puerarin concentration-dependently modulates SF hydrogel supramolecular organization and physicochemical properties.
  • The developed PUE-SF hydrogels are tunable, injectable, and cytocompatible.
  • These hydrogels show significant potential for soft tissue biomaterial applications.