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Cognitive, Motor and Oculomotor Contributions to the Trail Making Test in Progressive Supranuclear Palsy
Indira Garcia-Cordero1,2,3, Mohsen Hadian2, Juan Camilo Vargas-Gonzalez2
1Cognitive Neuroscience Center, Department of Life and Behavioral Sciences, Universidad de San Andrés, Buenos Aires, Argentina.
Background:
Progressive supranuclear palsy (PSP) is a neurodegenerative disorder characterized by motor, oculomotor and cognitive impairments. Yet disentangling cognitive deficits from motor and oculomotor dysfunction remains a diagnostic and methodological challenge.
Objectives:
This study aims to evaluate how cognitive, motor, and oculomotor impairments contribute to performance in the Trail Making Test (TMT) in PSP patients.
Methods:
Eighty-one patients with PSP-Richardson's syndrome underwent the Toronto Cognitive Assessment, the Movement Disorder Society Unified Parkinson's Disease Rating Scale-part III and the PSP rating scale. Structural equation modeling was used to examine associations between TMT performance, cognitive function, and motor/oculomotor measures derived from these assessments.
Results:
TMT performance was mainly driven by cognitive factors, particularly executive function, with no significant influence from motor or oculomotor deficits.
Conclusions:
These findings suggest that the TMT is a valuable tool for assessing cognitive impairment in PSP, reflecting fronto-striatal (associative loop) dysfunction rather than motor or oculomotor impairments.
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