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Related Concept Videos

Respiratory Assessment: Purpose and Indications01:19

Respiratory Assessment: Purpose and Indications

Respiratory assessment is a cornerstone of nursing assessments, crucial for the early detection of patient deterioration. This evaluation transcends routine procedures, representing a critical skill nurses must master to ensure optimal patient care.
Objectives and Importance:
The primary goal of respiratory assessment is to evaluate patients at early risk of clinical deterioration. Since respiratory distress often precedes other signs of declining health, breathing patterns and sounds become a...

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Updated: Jun 2, 2026

Breath Collection from Children for Disease Biomarker Discovery
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Respiratory Biomarkers: An Opportunity for Patient-Centric Microsampling Approach for Treatment Optimization.

Ahmar Khan1, Jacqueline L Stair1, Daniel Baker1

  • 1Department of Medicine, Applied and Clinical Sciences, School of Health, Medicine, and Life Sciences, University of Hertfordshire, Hatfield, Hertfordshire, UK.

Clinical and Translational Science
|June 1, 2026
PubMed
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Personalized respiratory disease therapy needs better biomarkers. Micro-sampling offers a less invasive way to collect blood samples at home, improving patient monitoring and treatment individualization.

Keywords:
clinical markersinter‐patient variabilitypatient‐centric samplingpersonalized medicinepulmonary disease

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Area of Science:

  • Pulmonary Medicine
  • Biomarker Discovery
  • Personalized Medicine

Background:

  • Respiratory disorders exhibit significant clinical heterogeneity, necessitating personalized approaches.
  • Blood-derived protein and peptide biomarkers are being investigated for improved respiratory disease management.
  • Current biomarker quantification methods are invasive, require clinical visits, and offer only single-time point data.

Purpose of the Study:

  • To explore novel respiratory biomarkers for personalized therapy.
  • To investigate the potential of micro-sampling techniques for respiratory biomarker analysis.
  • To highlight the future integration of micro-sampling into respiratory care pathways.

Main Methods:

  • Review of current literature on respiratory biomarkers.
  • Discussion of challenges in traditional blood sample collection for biomarker analysis.
  • Exploration of micro-sampling techniques for patient-centric blood collection.

Main Results:

  • Limited exploration of micro-sampling for respiratory disease biomarkers exists.
  • Micro-sampling shows promise for quantifying drugs and proteins from blood.
  • Novel respiratory biomarkers are emerging for disease stratification and treatment optimization.

Conclusions:

  • Micro-sampling techniques offer a minimally invasive, patient-centric approach to biomarker collection.
  • Integrating micro-sampling into care pathways can optimize and individualize respiratory disease therapy.
  • Further research is needed to fully exploit micro-sampling for respiratory biomarker analysis.