Quantitative methods for the risk assessment of drinking water contact chemicals following the NSF/ANSI/CAN 600
Bradley Lampe1, J Caroline English2, L T Haber3
1Health and Safety Science, NSF, Ann Arbor, MI, USA.
Abstract:
Health-based criteria have been developed using quantitative methods for over 370 unregulated chemicals that have been detected in extraction testing of products certified or being certified to NSF/ANSI/CAN 60 (Drinking Water Treatment Chemicals - Health Effects) and NSF/ANSI/CAN 61 (Drinking Water System Components - Health Effects), public health-based drinking water standards. These criteria are derived in accordance with the requirements of NSF/ANSI/CAN 600, Health Effects Evaluation and Criteria for Chemicals in Drinking Water and undergo external peer review by an independent Health Advisory Board. However, a complete and unified description of how these criteria are derived is not available in the scientific literature. This is the second part of a two-part publication that describes specialized methods that may be applied in drinking water risk assessments conducted according to NSF/ANSI/CAN 600, depending on data availability and understanding of the mode of action. The specialized methods discussed herein include the use of data-derived extrapolation factors (including dosimetric adjustment factors and chemical-specific adjustment factors), inhalation-to-oral route extrapolation, the use of threshold versus non-threshold approaches in evaluating dose-response, study mortality adjustments, benchmark dose modeling, and carcinogen-specific approaches such as the use of the cancer slope factor and lifestage adjustment for cancer potency.
More Related Videos
09:04Identifying Per- and Polyfluorinated Chemical Species with a Combined Targeted and Non-Targeted-Screening High-Resolution Mass Spectrometry Workflow
Published on: April 18, 2019
09:51TD-DFT Guided Advanced E-Eye Sensing Technique for On-site Quantification of Fe, Cr, F, and As in the Environmental, Biological, and Food Samples
Published on: September 19, 2025
Related Concept Videos
Quality of Water
Testing Water Quality
Quantitative Analysis
In quantitative analysis, two key measurements are made: the sample quantity and a property proportional to the amount of the analyte (the substance being analyzed). This forms the basis of the method...
Development of Analytical Methods
Data Validation
Key parameters for method validation include:
Gravimetry: Overview
In precipitation gravimetry, the analyte is converted into a precipitate and weighed. For example, the silver content in a sample can be estimated by precipitating and...
