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Related Concept Videos

Hearing01:31

Hearing

When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.

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Updated: Jun 2, 2026

Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages
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Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages

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Predisposing Factors for Congenital Hearing Loss: A Comprehensive Systematic Review.

Taruni Lalchandani1, Ashish Chandra Agarwal1, Shiva Tiwari2

  • 1Dr. Ram Manohar Lohia Institute of Medical Sciences, Department of Otorhinolaryngology, Uttar Pradesh, India.

Turkish Archives of Otorhinolaryngology
|June 1, 2026
PubMed
Summary

Congenital hearing loss (CHL) is often caused by genetic factors and infections like cytomegalovirus. Early detection and prevention strategies targeting these key risk factors are essential for managing CHL in children.

Keywords:
Congenital, hearing losscongenital infectionsdiseasesenvironmental exposuregenetic predisposition to diseaseinfantnewbornototoxicity

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Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
09:44

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss

Published on: January 25, 2016

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Last Updated: Jun 2, 2026

Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages
09:09

Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages

Published on: April 11, 2025

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
09:44

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss

Published on: January 25, 2016

Area of Science:

  • Otolaryngology
  • Genetics
  • Pediatrics

Background:

  • Congenital hearing loss (CHL) is a significant global health concern.
  • Identifying risk factors is crucial for prevention and early intervention.
  • CHL has diverse etiologies, including genetic, infectious, perinatal, and environmental factors.

Purpose of the Study:

  • To systematically review and synthesize research on risk factors for congenital hearing loss (CHL).
  • To emphasize genetic, infectious, perinatal, environmental, and sociodemographic influences on CHL.
  • To inform targeted screening and preventive strategies for CHL.

Main Methods:

  • Systematic review adhering to PRISMA 2020 and PRISMA-S guidelines.
  • Comprehensive literature search across PubMed, Embase, Scopus, and Google Scholar.
  • Inclusion of observational studies assessing CHL risk factors; risk of bias evaluation using established tools.

Main Results:

  • Genetic factors (e.g., GJB2 mutations, family history, consanguinity) and infections (e.g., congenital cytomegalovirus, TORCH) are prevalent causes of CHL.
  • Perinatal issues (NICU admission, low birth weight, hyperbilirubinemia) and ototoxic medication exposure are significant risk factors.
  • Sensorineural hearing loss, predominantly bilateral, is the most common type reported.

Conclusions:

  • Congenital hearing loss is a multifactorial condition with significant genetic and infectious contributions.
  • Effective management requires targeted screening and preventive measures addressing identified risk domains.
  • Further research can refine understanding and improve outcomes for children with CHL.