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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

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Diagnostic studies
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Related Experiment Video

Updated: Jun 2, 2026

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis
14:54

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis

Published on: January 27, 2019

Plant-Based Diet and Risk of Sepsis: A 16-Year Follow-Up Study.

Shaokang Xu1,2, Ziqiao Fang3,4,5, Xiaoke Kong3,4,5

  • 1Department of Critical Care Medicine and Hematology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.

Critical Care Medicine
|June 1, 2026
PubMed
Summary

A healthy plant-based diet may lower sepsis risk, while an unhealthy one increases it. These dietary patterns influence sepsis risk, potentially through metabolic and inflammatory pathways.

Keywords:
inflammationmetabolismplant-based dietprospective studysepsis risk

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Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies
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Published on: April 11, 2012

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Last Updated: Jun 2, 2026

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis
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Published on: January 27, 2019

Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies
07:34

Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies

Published on: April 11, 2012

Area of Science:

  • Nutritional epidemiology
  • Preventive medicine
  • Clinical nutrition

Background:

  • Plant-based diets show potential for metabolic and immune health.
  • Limited evidence exists on plant-based diets and sepsis prevention.
  • Sepsis is a life-threatening condition requiring effective preventive strategies.

Purpose of the Study:

  • To investigate the association between plant-based dietary patterns and sepsis risk.
  • To differentiate the impact of healthy versus unhealthy plant-based diets on sepsis incidence.
  • To explore potential mediating pathways for these associations.

Main Methods:

  • Prospective cohort study utilizing UK Biobank data.
  • Inclusion of 180,442 participants with a median follow-up of 13 years.
  • Construction of plant-based diet indices (PDI, hPDI, uPDI) from food group data.
  • Cox proportional hazards regression and mediation analyses.

Main Results:

  • Higher adherence to overall (PDI) and healthy plant-based diets (hPDI) correlated with reduced sepsis risk.
  • Increased adherence to unhealthy plant-based diets (uPDI) was linked to a higher risk of sepsis.
  • Mediation analysis indicated that metabolic and inflammatory biomarkers partially explain these associations.

Conclusions:

  • Adherence to healthy plant-based diets is associated with lower sepsis risk.
  • Unhealthy plant-based diets are linked to increased sepsis risk, independent of other factors.
  • Diet quality plays a role in sepsis prevention, potentially via metabolic and inflammatory mechanisms.