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The Association Between Immune Cells and Venous Thromboembolism: A Causal Inference Based on Mendelian Randomization.
Jingyi Zhu1,2, Jiamei Chen1,2, Yanxiao Wang1,2
1Zhejiang Key Laboratory of Medical Epigenetics, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Summary
Immune cell phenotypes impact venous thromboembolism (VTE) risk. Specific immune traits show protective effects, while others increase VTE risk, offering new insights for prevention and treatment.
Area of Science:
- Immunology
- Genetics
- Vascular Medicine
Background:
- Emerging evidence links immune cells to venous thromboembolism (VTE).
- The specific roles of distinct immune cell phenotypes in VTE pathogenesis are not well understood.
Purpose of the Study:
- To investigate the causal associations between various immune traits and VTE risk.
- To identify specific immune cell phenotypes that influence the risk of deep vein thrombosis (DVT) and pulmonary embolism (PE).
Main Methods:
- Utilized genome-wide association studies (GWAS) data from the FinnGen database for 731 immune traits.
- Applied two-sample Mendelian randomization (MR) and Bayesian colocalization analysis (COLOC).
- Performed rigorous quality control and sensitivity analyses for robust findings.
Main Results:
- Identified negative associations between certain T cell phenotypes (e.g., naive CD4+ T cells) and overall VTE risk.
- Found specific immune cell associations with DVT (CD45RA+ CD8+ T cell AC) and PE (e.g., HLA DR+ NK cells, CD86+ myeloid dendritic cells).
- COLOC analysis confirmed a genetic colocalization between naive CD4+ T cell AC variants and VTE.
Conclusions:
- Different immune cell phenotypes exert either protective or risk-increasing effects on VTE.
- Findings enhance understanding of VTE pathophysiology.
- Provides valuable insights for future research and clinical applications in VTE management.
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