Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Endoscopic Procedures V: ERCP01:26

Endoscopic Procedures V: ERCP

Endoscopic Retrograde Cholangiopancreatography (ERCP) is a diagnostic procedure that combines endoscopy and fluoroscopy to diagnose and treat conditions related to the bile ducts, pancreatic ducts, and gallbladder. This procedure is beneficial for identifying and addressing blockages, gallstones, strictures, and tumors within the biliary or pancreatic systems. ERCP is both diagnostic and therapeutic, offering the ability to visualize and treat identified problems in one session.
Patient...
Peptic Ulcer Disease III: Clinical Manifestations and Complications01:25

Peptic Ulcer Disease III: Clinical Manifestations and Complications

Duodenal UlcersDuodenal ulcers are the most common form of peptic ulcer disease, presenting with chronic, intermittent epigastric pain. Pain typically appears 2–3 hours after meals, especially when the stomach is empty, often waking patients at night. It is characteristically relieved by food or antacids (“pain–food–relief”). Some patients remain asymptomatic until complications like bleeding or perforation emerge, particularly with NSAID or anticoagulant use.Gastric UlcersGastric ulcers share...
Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gestational Outcomes and Time to Subsequent Pregnancy After Acute Pancreatitis: A Nationwide Cohort Study.

Gastro hep advances·2026
Same author

Acute fatal delayed subdural hemorrhage diagnosed with head computed tomography scan 19 days after hospital admission: A case report.

Radiology case reports·2026
Same author

Prior bariatric surgery and better short-term outcomes in acute pancreatitis: a multicenter propensity-matched analysis.

Annals of gastroenterology·2026
Same author

Removal of a Decade-Long Indwelling Lumen-Apposing Metal Stent for Post-Roux-en-Y Gastric Bypass Gastrojejunostomy Stricture.

ACG case reports journal·2026
Same author

Target Trial Emulation of 6-Month Weight Change after Endoscopic Sleeve Gastroplasty and Sleeve Gastrectomy: A Retrospective Cohort Study.

Journal of the American College of Surgeons·2026
Same author

Mechanical and manual cardiopulmonary resuscitation in traumatic cardiac arrest: a retrospective observational study.

European journal of trauma and emergency surgery : official publication of the European Trauma Society·2026

Related Experiment Videos

High-Risk Comorbidities Drive Adverse Inpatient Outcomes After ERCP: A National Analysis and Predictive Model.

Zachary D Leslie1, Khalid Ahmed2, Yasmin Ali3

  • 1Carleton College, Northfield, MN, USA.

Digestive Diseases and Sciences
|June 1, 2026
PubMed
Summary

Patients with chronic kidney disease, congestive heart failure, or liver cirrhosis undergoing ERCP have significantly worse outcomes. These adverse events are primarily driven by underlying conditions, not ERCP complications, impacting mortality and morbidity.

Keywords:
Chronic kidney diseaseCongestive heart failureERCP outcomesEndoscopic retrograde cholangiopancreatographyHigh-risk comorbiditiesLiver cirrhosisMorbidityMortalityNational inpatient samplePredictive modelingRisk stratification

Related Experiment Videos

Area of Science:

  • Gastroenterology
  • Nephrology
  • Cardiology
  • Hepatology

Background:

  • Patients undergoing Endoscopic Retrograde Cholangiopancreatography (ERCP) with chronic kidney disease (CKD), congestive heart failure (CHF), or liver cirrhosis (LC) often experience poorer outcomes.
  • The contribution of procedure-related events versus underlying comorbidities to these adverse outcomes remains unclear.

Purpose of the Study:

  • To investigate the impact of high-risk comorbidities (CKD, CHF, LC) on inpatient outcomes following ERCP.
  • To determine whether adverse events are primarily driven by the procedure itself or by pre-existing conditions.

Main Methods:

  • Analysis of the National Inpatient Sample database to identify adult ERCP admissions.
  • Definition of high-risk comorbidities as CKD, CHF, or LC.
  • Evaluation of primary outcomes including inpatient mortality and morbidity, length of stay (LOS), and hospital charges.

Main Results:

  • Nearly a quarter (22.8%) of 1,171,973 ERCP admissions involved patients with high-risk comorbidities.
  • High-risk patients exhibited significantly higher inpatient mortality (3.8% vs. 0.8%) and morbidity (71.8% vs. 35.7%) compared to lower-risk patients.
  • Adjusted models confirmed high-risk comorbidities independently predicted mortality (OR 3.80) and morbidity (OR 3.22), with LC being the strongest predictor of mortality and CHF of morbidity.

Conclusions:

  • High-risk comorbidities are prevalent in ERCP admissions and are strong independent predictors of adverse inpatient outcomes.
  • The majority of negative outcomes appear to stem from the severity of underlying illnesses rather than ERCP-specific complications.
  • Validated predictive models can aid in patient counseling, triage, and peri-procedural management for high-risk ERCP patients.