The Role of Lacticaseibacillus Rhamnosus in Periodontitis Management: From Microecological Regulation to Clinical...

Area of Science:

• Periodontology
• Microbiology
• Immunology

Background:

• Periodontitis is a chronic inflammatory disease driven by microbial imbalance.
• Current treatments like mechanical therapy have limitations, and antibiotic resistance is a growing concern.
• New adjunctive strategies are needed for periodontitis management.

Purpose of the Study:

• To explore the potential of probiotic therapy, specifically Lacticaseibacillus rhamnosus (L. rhamnosus), as an adjunctive treatment for periodontitis.
• To review the therapeutic effects and clinical applications of L. rhamnosus in modulating periodontal microecology.

Main Methods:

• Literature review of clinical trials and studies on L. rhamnosus for periodontitis.
• Analysis of L. rhamnosus mechanisms including pathogen inhibition, immune modulation, and tissue repair.
• Evaluation of safety and effectiveness data from human studies.

Main Results:

• L. rhamnosus demonstrates therapeutic effects by inhibiting periodontal pathogens and modulating host immune responses.
• Clinical trials confirm the safety and effectiveness of L. rhamnosus as an adjuvant therapy for periodontitis.
• The probiotic has been applied in various forms, showing broad potential for application.

Conclusions:

• L. rhamnosus is a promising probiotic for periodontitis adjuvant therapy, offering benefits beyond traditional mechanical approaches.
• Further research is needed to clarify strain-specific effects and standardize administration protocols for optimal clinical use.
• Targeted interventions and investigation into mechanisms are crucial for advancing probiotic therapy in diverse patient populations.