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Updated: Jun 2, 2026
04:18
Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice
Published on: October 10, 2025
Rare vasculitis types and obstetric and neonatal outcomes - A population-based study
Uri Amikam1,2, Ahmad Badeghiesh3,4, Haitham Baghlaf5
1Department of Obstetrics and Gynecology, McGill University, Montréal, Quebec, Canada.
Summary
Women with rare vasculitis face increased risks of pregnancy complications like hypertensive disorders, preterm birth, and cesarean delivery. These conditions also elevate the risk of congenital anomalies in newborns.
Area of Science:
- Reproductive Medicine
- Rheumatology
- Maternal-Fetal Medicine
Background:
- Vasculitis is uncommon in reproductive-aged women.
- Limited data exists on pregnancy outcomes for rare vasculitis subtypes.
Purpose of the Study:
- To compare pregnancy and perinatal outcomes in women with rare vasculitis versus those without.
- To identify specific risks associated with rare vasculitis during pregnancy.
Main Methods:
- Retrospective cohort study using the HCUP-NIS (2004-2014).
- Included pregnant women with rare vasculitis diagnoses (e.g., Polyarteritis nodosa, Takayasu arteritis).
- Compared outcomes using multivariate logistic regression.
Main Results:
- Women with rare vasculitis had higher rates of hypertensive disorders (aOR 1.89), preterm delivery (aOR 1.76), and cesarean delivery (aOR 1.31).
- Increased risk of congenital anomalies (aOR 4.1) observed in the rare vasculitis group.
- Higher rates of blood product transfusion noted in the study group.
Conclusions:
- Rare vasculitis is associated with significantly higher maternal complication rates.
- Pregnancy in women with rare vasculitis increases the risk of adverse perinatal outcomes, including congenital anomalies.
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