Rising Lung Cancer Burden Attributable to High Fasting Plasma Glucose in Women Aged ≥50 Years: Age-, SDI-, and
Lili Lin1, Xiaoqin Huang1, Bijun Li1
1Guangdong Pharmaceutical University First Affiliated Hospital, Guangzhou, China.
Introduction:
We quantified trends and heterogeneity in lung cancer burden attributable to high fasting plasma glucose (HFPG) among women aged ≥50 years (used as a population-level proxy for postmenopausal status) globally and across BRICS countries from 1990 to 2021.
Methods:
HFPG-attributable lung cancer deaths and disability-adjusted life years (DALYs) for women aged ≥50 years were obtained from Global Burden of Disease 1990-2021. Burden was summarized as numbers and age-standardized rates (ASR) per 100,000, stratified by age, Socio-demographic Index (SDI) quintile, and country. Trends were assessed using estimated annual percentage change (EAPC) from log-linear regression.
Results:
Global HFPG-attributable deaths and DALYs increased markedly from 1990 to 2021, with rising ASR (global EAPC 1.21; 95% CI, 1.11-1.31). A strong age gradient was observed; EAPC increased from 0.53% (50-54 years) to 3.65% (≥95 years). In 2021, the DALYs ASR peaked in the 75-79 years group (59.38 per 100,000). High-SDI settings consistently had the highest ASR and increasing burden. In BRICS, the ASR of DALYs increased in all five countries with substantial heterogeneity; India showed the fastest increase (EAPC 3.05; 95% CI, 2.91-3.19), followed by South Africa (2.82; 2.64-3.00), and Brazil (2.36; 2.31-2.42), while China showed the smallest increase (0.87; 0.70-1.03).
Conclusion:
HFPG-attributable lung cancer burden in women aged ≥50 years rose substantially from 1990 to 2021, with disproportionate growth in older ages and clear SDI/BRICS differences, supporting integrated metabolic prevention within cancer control and healthy aging strategies.
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