Related Experiment Video
Updated: Jun 3, 2026

Understanding the Development of Compensatory Pathways in a Mutant Malaria Parasite Harbouring Hypomorphic Allele of Plant-Like Kinases
Published on: November 22, 2024
Plasmodium Phosphatidylinositol 4-Kinase Beta (PI4Kβ): An Emerging Target at the Interface of Parasite Biology and
Vijaykumar D Nimbarte1, Shreya S Sonak2, Nirlipta Mohapatra3
1Department of Pharmacy, Birla Institute of Technology and Science (BITS) Pilani, Hyderabad Campus, Dist. Medchal,500078, Telangana State, India.
Abstract:
Phosphatidylinositol 4-kinase beta (PI4Kβ) is an essential lipid kinase in Plasmodium species, central to intracellular signaling, vesicular trafficking, and parasite development. Recent insights suggest PI4Kβ also plays a key role in modulating host immune responses. Through regulation of protein export, immune evasion mechanisms, and extracellular vesicle formation, PI4Kβ influences the immune landscape during malaria infection. Notably, inhibition of PI4Kβ disrupts parasite survival and may enhance immune recognition by impairing virulence factor trafficking and improving antigen presentation. Targeting PI4Kβ offers a promising dual-action strategy-direct antiplasmodial effects coupled with immunomodulation. This review explores PI4Kβ's emerging role at the interface of parasite survival and host immunity, highlighting its therapeutic potential as both an antiparasitic and immunomodulatory target. Further investigation is warranted to evaluate its role in antigen processing, vaccine responsiveness, and combinatorial immunotherapy. PI4Kβ stands out as a next-generation target for integrated malaria intervention strategies.
More Related Videos
08:07Identification of Inositol Phosphate or Phosphoinositide Interacting Proteins by Affinity Chromatography Coupled to Western Blot or Mass Spectrometry
Published on: July 26, 2019
08:20In Vitro Assay of Plasmodium-Infected Red Blood Cell Killing by Cytotoxic Lymphocytes
Published on: August 17, 2022
Related Concept Videos
Malaria
Phosphoinositides and PIPs
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...
PI3K/mTOR/AKT Signaling Pathway
Amebiasis
The JAK-STAT Signaling Pathway
Diversity of Protists II