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Updated: Jun 3, 2026

Normothermic Machine Perfusion of Rat Kidneys for Transplantation

Normothermic Machine Perfusion of Rat Kidneys for Transplantation

Published on: January 27, 2026

Kidney Container for Organ Perfusion Machines.

Loraine C Goenaga-Mafud¹, José D Vollet-Filho¹, Daniel J Chianfrone¹

¹From the Sao Carlos Institute of Physics (IFSC), University of Sao Paulo (USP), Sao Carlos, São Paulo, Brazil.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)

|June 1, 2026

Summary

A new disposable Renal Container for hypothermic machine perfusion shows promise for kidney transplantation. This affordable device maintained kidney tissue integrity during a 4-hour perfusion trial, aiding organ preservation.

Keywords:

disposable renal container hypothermic perfusion invention patent kidney transplant perfusion machine

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Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation

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Published on: July 15, 2015

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Last Updated: Jun 3, 2026

Normothermic Machine Perfusion of Rat Kidneys for Transplantation

Normothermic Machine Perfusion of Rat Kidneys for Transplantation

Published on: January 27, 2026

Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation

Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation

Published on: July 15, 2015

Area of Science:

Biomedical Engineering
Transplantation Science
Medical Device Innovation

Background:

Organ transplantation, particularly kidney transplants, significantly improves patient quality of life.
Hypothermic machine perfusion (HMP) is a critical technique for preserving donor kidneys.
There is a need for cost-effective, single-use consumables for HMP systems.

Purpose of the Study:

To describe a novel, single-use Renal Container for hypothermic machine perfusion.
To evaluate the performance and safety of the Renal Container in pilot HMP experiments.

Main Methods:

The Renal Container, a flexible polyvinyl chloride (PVC) receptacle with an integrated kidney cradle, was designed as a disposable product.
Pilot studies were conducted using the Renal Container in a hypothermic machine perfusion setup.
Perfusion performance was monitored over a 4-hour period, and renal tissues were examined histologically.

Main Results:

The Renal Container demonstrated good performance during 4 hours of hypothermic machine perfusion.
No visible histological alterations were observed in the perfused renal tissues, indicating tissue viability.
The container's design facilitated kidney accommodation and process integration.

Conclusions:

The single-use Renal Container is a viable and potentially cost-effective adjunct for hypothermic machine perfusion in kidney transplantation.
The device shows potential for preserving donor kidney integrity during transport and preservation.
Further studies are warranted to validate its efficacy in larger clinical trials.