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Autoimmune Disorders

Autoimmune Disorders

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Related Experiment Video

Updated: Jun 3, 2026

Manufacturing Chimeric Antigen Receptor (CAR) T Cells for Adoptive Immunotherapy

Manufacturing Chimeric Antigen Receptor (CAR) T Cells for Adoptive Immunotherapy

Published on: December 17, 2019

CAR T cells for systemic autoimmune diseases.

Florencia Rosetti¹, Iris K Madera-Salcedo¹, Luis A Cenobio²

¹Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, Mexico.

Autoimmunity Reviews

|June 1, 2026

Summary

Chimeric antigen receptor (CAR) T cells, a novel cellular therapy, show promise in treating severe autoimmune diseases like lupus. This review explores CAR T-cell therapy, its mechanisms, and future directions for managing autoimmunity.

Keywords:

Advanced cellular therapies CAR T cells Chimeric antigen receptor Idiopathic inflammatory myopathies Immune resetting Systemic lupus erythematosus Systemic sclerosis

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High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model

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Last Updated: Jun 3, 2026

Manufacturing Chimeric Antigen Receptor (CAR) T Cells for Adoptive Immunotherapy

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Published on: December 17, 2019

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography

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High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model

High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model

Published on: August 16, 2019

Area of Science:

Immunology
Cellular Therapy
Autoimmunity

Background:

Chimeric antigen receptor (CAR) T cells are engineered immune cells targeting specific antigens.
Anti-CD19 CAR T cells are approved for B cell malignancies and show efficacy in autoimmune diseases.

Purpose of the Study:

To review the fundamentals of CARs and CAR T cells.
To discuss their application and effectiveness in systemic autoimmune diseases.
To explore future prospects of CAR T-cell therapy in autoimmunity.

Main Methods:

Literature review of CAR T-cell therapy in autoimmune diseases.
Discussion of CAR T-cell mechanisms of action.
Overview of current research and future trends.

Main Results:

CAR T cells demonstrate significant efficacy in severe refractory autoimmune conditions.
Mechanisms of clinical effectiveness are being elucidated.
The therapy offers new insights into autoimmune disease pathogenesis.

Conclusions:

CAR T-cell therapy is a promising new treatment for severe autoimmune diseases.
Long-term effects require further investigation.
This approach enhances understanding of systemic autoimmunity.