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Related Experiment Video

Updated: Jun 3, 2026

Rapid and Low-cost Prototyping of Medical Devices Using 3D Printed Molds for Liquid Injection Molding
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Rapid and Low-cost Prototyping of Medical Devices Using 3D Printed Molds for Liquid Injection Molding

Published on: June 27, 2014

MOLD: Modular layout designer for Echo liquid handlers.

Pavel Kraina1, Matúš Drexler1

  • 1Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, 16000 Prague 6, Czech Republic.

SLAS Technology
|June 1, 2026
PubMed
Summary
This summary is machine-generated.

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MOLD is a new open-source tool for high-throughput screening (HTS) that simplifies experimental plate layout generation. This KNIME-based application enhances drug discovery by optimizing liquid handling for acoustic systems, improving efficiency and reproducibility.

Area of Science:

  • Biochemistry
  • Bioinformatics
  • Laboratory Automation

Background:

  • High-throughput screening (HTS) relies on advanced liquid handling for drug discovery.
  • Acoustic liquid handling systems (e.g., Echo series) offer precision but lack accessible open-source layout tools.
  • Efficient experimental design and execution are crucial for scalability in HTS.

Purpose of the Study:

  • To introduce MOLD, a novel KNIME-based application for customizable experimental plate layout generation in HTS.
  • To bridge the gap between experimental design and execution for acoustic liquid handling systems.
  • To provide an open-source solution for optimizing transfer volumes and dilution series in high-throughput pipelines.

Main Methods:

  • Development of MOLD, a KNIME workflow application.
Keywords:
Echo liquid handlerKNIME workflowLayout designerOpen-source software

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Last Updated: Jun 3, 2026

Rapid and Low-cost Prototyping of Medical Devices Using 3D Printed Molds for Liquid Injection Molding
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Published on: June 27, 2014

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  • Integration of MOLD with Echo acoustic liquid handling systems.
  • Implementation of algorithms for custom dilution series calculation and transfer volume optimization.

    • Main Results:

    • MOLD enables seamless, customizable experimental plate layout generation.
    • The application optimizes transfer volumes and ensures compatibility with high-throughput workflows.
    • MOLD facilitates the creation of custom dilution series for dose-response experiments.

    Conclusions:

    • MOLD enhances reproducibility, scalability, and time efficiency in HTS.
    • The open-source nature of MOLD promotes accessibility in academic and industrial research.
    • MOLD represents a significant advancement in streamlining HTS experimental design and execution.