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Related Experiment Video

Updated: Jun 3, 2026

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound (30/45MHZ) System

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound (30/45MHZ) System

Published on: May 5, 2018

Spontaneous Preterm Birth and Subsequent Cardiovascular Mortality: Linked Registry Cohort Study.

Sophie M Welters^1,2, Christianne J M De Groot^1,2, Esmé I Kamphuis^1,3

¹Department of Obstetrics and Gynecology, Amsterdam UMC-VU University Medical Center, Amsterdam, the Netherlands.

BJOG : an International Journal of Obstetrics and Gynaecology

|June 1, 2026

Summary

Women with a history of spontaneous preterm birth (PTB) face increased cardiovascular mortality (CVM) risk. Early spontaneous PTB before 32 weeks gestation significantly elevates this risk.

Keywords:

cardiovascular risk follow‐up preterm birth women's health

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A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis

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Area of Science:

Reproductive Health
Cardiovascular Epidemiology
Perinatal Medicine

Background:

Preterm birth (PTB) is a significant public health concern.
The long-term cardiovascular health implications for women following PTB require further investigation.

Purpose of the Study:

To determine the cardiovascular mortality (CVM) risk in women with a history of spontaneous preterm birth (PTB).

Main Methods:

Population-based cohort study in the Netherlands.
Data linkage between National hospital Birth Registry and National Death Registry (1995-2017).
Analysis of CVM in women with any PTB and spontaneous PTB, with subgroup analysis for PTB < 32 weeks.

Main Results:

A cohort of 1,166,476 women was analyzed.
Women with spontaneous PTB had a higher CVM risk (aHR 1.38) compared to term birth.
Early spontaneous PTB (< 32 weeks gestation) showed the highest CVM risk (aHR 3.19).

Conclusions:

Women with spontaneous PTB have an elevated CVM risk, particularly those with early PTB (< 32 weeks).
This elevated risk may be linked to vascular mechanisms in a specific subgroup of spontaneous PTB.