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Related Experiment Video

Updated: Jun 3, 2026

Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording
06:36

Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording

Published on: September 1, 2022

Neuropixels Opto: combining high-resolution electrophysiology and optogenetics.

Anna A Lakunina1, Karolina Z Socha2, Alexander E Ladd3

  • 1Allen Institute for Neural Dynamics, Seattle, WA, USA.

Nature Methods
|June 1, 2026
PubMed
Summary
This summary is machine-generated.

New Neuropixels Opto probes combine high-resolution neural recording with optogenetic stimulation. These advanced tools enable precise manipulation and identification of neuronal populations in the brain.

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Area of Science:

  • Neuroscience
  • Bioengineering
  • Electrophysiology

Background:

  • High-resolution extracellular electrophysiology is crucial for studying neural populations.
  • Optogenetics allows precise temporal control over specific cell types.
  • Combining these techniques offers powerful insights into neural circuit function.

Purpose of the Study:

  • To integrate electrophysiology and optogenetics into a single probe.
  • To develop a tool for simultaneous recording and manipulation of neural activity.
  • To assess the performance of the integrated probe in vivo.

Main Methods:

  • Development of Neuropixels Opto probes with 960 recording sites and light emitters.
  • Integration of electronic and photonic circuits on a narrow shank.
  • In vivo testing in mouse cortex and striatum for recording and optogenetic stimulation.

Main Results:

  • Neuropixels Opto probes achieved high-quality recordings alongside spatially addressable optogenetics.
  • Differential activation/silencing of neurons at various cortical depths was demonstrated.
  • Efficient optotagging in deep brain structures identified multiple cell types concurrently.

Conclusions:

  • Neuropixels Opto probes successfully combine electrophysiology and optogenetics.
  • This technology enables precise manipulation and identification of neuronal populations.
  • The probes represent a significant advancement for neuroscience research.