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Neonatal epicutaneo-cava catheter-related thrombosis: a comprehensive overview
1Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.
Thrombosis Journal
|June 2, 2026
Summary
Neonatal peripherally inserted central catheters (n-PICC) can cause catheter-related thrombosis (CRT). This review offers clinical guidance on managing CRT in neonates due to their unique coagulation system challenges.
Area of Science:
- Neonatal medicine
- Pediatric thrombosis
- Vascular access devices
Background:
- Peripherally inserted central catheters (n-PICC) are essential for neonatal care, enabling long-term nutrition and medication delivery.
- Catheter-related thrombosis (CRT) is a significant complication associated with n-PICC use in neonates.
- Neonates possess an immature coagulation system, predisposing them to a higher risk of thrombosis.
Purpose of the Study:
- To review current knowledge on risk factors, diagnosis, and management of CRT in neonates.
- To provide evidence-based clinical guidance for CRT in this vulnerable population.
- To highlight the lack of standardized protocols for CRT in neonates.
Main Methods:
- Comprehensive literature review of studies on n-PICC and CRT in neonates.
- Analysis of risk factors, diagnostic modalities, and treatment strategies.
- Synthesis of information to formulate clinical recommendations.
Main Results:
- Identified key risk factors contributing to CRT in neonates.
- Summarized current diagnostic approaches, including imaging techniques.
- Outlined various treatment and preventive strategies for CRT.
Conclusions:
- CRT is a prevalent and serious complication of n-PICC in neonates.
- Standardized diagnostic and management protocols are urgently needed.
- This review provides a foundation for developing such protocols to improve neonatal outcomes.
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