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Related Experiment Video

Updated: Jun 3, 2026

Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice

Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice

Published on: February 3, 2016

Computational Quantification of Peristalsis in Preclinical Mouse Models Using Smartphone Videography.

Joseph C Schindler^1,2, Gargi Vijayan Pillai³, Thomas M Raffay⁴

¹Institute for Transformative Molecular Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

Neurogastroenterology and Motility

|June 2, 2026

Summary

A new computational method quantifies gut peristalsis in mice using mobile phone videos. This tool aids in preclinical research for drug screening and understanding gastrointestinal motility changes.

Keywords:

computational method motility peristalsis smartphone

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Last Updated: Jun 3, 2026

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Area of Science:

Gastroenterology
Computational Biology
Preclinical Research

Background:

Gastrointestinal motility disorders impact numerous diseases and treatments.
Existing methods for measuring peristalsis in vivo are often impractical and lack standardization.

Purpose of the Study:

To develop a novel, accessible computational method for quantifying gut peristalsis.
To enable standardized, quantitative analysis of gastrointestinal motility in preclinical models.

Main Methods:

A computational pipeline was developed to analyze videographic data from mobile phone recordings.
The method tracks motion correlating to gastrointestinal transit in preclinical mouse models.

Main Results:

The method successfully quantified peristalsis in various mouse models, including germ-free and conventionally housed.
It detected and measured changes in gut motility influenced by drugs (methacholine), microbiome composition, and colonic anatomy.

Conclusions:

This computational tool offers a versatile solution for preclinical drug screening and mouse model evaluation.
The methodology has the potential for expansion to non-gastrointestinal applications.