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Updated: Jun 3, 2026
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Establishing a Competing Risk Regression Nomogram Model for Survival Data
Published on: October 23, 2020
Quantifying Survival and Mortality in Childhood Cancer Survivors
Emily S Tonorezos1, Jennifer M Yeh2
1Department of Medicine, Weill Cornell Medicine, New York, New York.
Summary
Childhood cancer survivors face a higher risk of early death, but survival rates are improving. This study shows better 5-year survival for many childhood cancers and a lower mortality ratio overall.
Area of Science:
- Cancer Epidemiology
- Survival Analysis
- Public Health
Background:
- Childhood and adolescent cancer survivors have an increased risk of premature mortality.
- Quantifying this mortality risk in a growing young population presents challenges.
Purpose of the Study:
- To analyze trends in 5-year relative survival and mortality ratios for childhood and adolescent cancer survivors.
- To identify specific cancer types with improved survival outcomes.
Main Methods:
- Utilized data from the Surveillance, Epidemiology, and End Results (SEER) program.
- Analyzed survival and mortality data from 1975 to 2020.
Main Results:
- Overall 5-year relative survival has improved significantly between 1975 and 2020.
- A decline in the standardized mortality ratio was observed.
- Improved 5-year relative survival was noted for lymphoid leukemia, Hodgkin lymphoma, non-Hodgkin lymphoma, and central nervous system tumors.
Conclusions:
- Findings indicate progress in managing childhood and adolescent cancers.
- Results have implications for healthcare policy, clinical practice, and research directions.
- Continued monitoring and research are essential for improving long-term outcomes.
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