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Updated: Jun 3, 2026
08:22
Remotely Supervised Transcranial Direct Current Stimulation: An Update on Safety and Tolerability
Published on: October 7, 2017
Summary
The pan-RAS inhibitor daraxonrasib doubled overall survival in pancreatic cancer patients compared to chemotherapy. This finding establishes daraxonrasib as a new standard of care for metastatic pancreatic ductal adenocarcinoma.
Area of Science:
- Oncology
- Medical research
Background:
- Pancreatic ductal adenocarcinoma (PDAC) remains a challenging cancer with limited treatment options.
- RAS pathway mutations are common in PDAC, driving tumor growth and resistance.
Purpose of the Study:
- To evaluate the efficacy of the pan-RAS inhibitor daraxonrasib versus chemotherapy in patients with metastatic PDAC.
- To establish a new standard-of-care for second-line treatment in this patient population.
Main Methods:
- A phase III clinical trial was conducted comparing daraxonrasib to standard chemotherapy.
- Overall survival was the primary endpoint assessed.
Main Results:
- Daraxonrasib demonstrated a doubling of overall survival compared to chemotherapy.
- The study presented data at the American Society of Clinical Oncology Annual Meeting.
Conclusions:
- Daraxonrasib represents a significant advancement in treating metastatic pancreatic ductal adenocarcinoma.
- The drug is poised to become the new standard-of-care for second-line treatment.
- Further research into RAS-targeted therapies is warranted.
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