Age-Associated Variations in Complete Blood Cell Count Parameters and Derived Indices Among Community-Dwelling...

This study aims to systematically characterize the physiological trajectories of complete blood cell count (CBC) parameters and their derived inflammatory indicators with age, providing high-quality evidence for assessing immunosenescence and the health of the elderly.

This cross-sectional study initially recruited 9331 participants aged 24-97 years. After applying exclusion criteria, 1630 healthy individuals were included for analysis. Data are presented as median (2.5th-97.5th percentiles). The Kruskal-Wallis test followed by Dunn's test with Bonferroni correction was used to compare CBC parameters and their derived indicators among four age groups within each sex. The Mann-Whitney U test was used to compare differences between males and females within each age group.

Red blood cell (RBC), hemoglobin (HGB), hematocrit (HCT), and mean corpuscular hemoglobin concentration (MCHC) decreased with age, while mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and red blood cell distribution width (RDW-CV) increased; sex-specific differences persisted in most parameters. Monocyte percentage and absolute count gradually increased with age; other white blood cell differentials showed variable patterns. Among CBC derived indicators: PLR and SII decreased with age; MLR remained low with limited variability in males; NLR exhibited a fluctuating trend across age groups. Platelet (PLT) progressively decreased with age.

The comprehensive dataset generated in this study has allowed observation of dynamic profiles of CBC parameters and their derived indicators in the healthy elderly population. This provides scientific evidence and theoretical support for aging and health assessment as well as chronic disease management among older adults.