Glioma-related epilepsy in patients with oligodendroglioma, IDH-mutant, and 1p/19q-codeleted: A single-institute
Jiajia Liu1, Yu Song2, Jiahan Dong1
1Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Purpose:
The current study aimed to investigate the clinical correlation of glioma-related epilepsy (GRE) in patients with IDH-mutant and 1p/19q-codeleted oligodendrogliomas.
Methods:
Data from 331 oligodendroglioma patients were retrospectively analyzed. Demographic and clinical characteristics associated with GRE were explored by groupwise comparisons. Kaplan-Meier analysis and COX analysis assessed the prognostic value of preoperative GRE for survival outcomes. Binary logistic regression was applied to explore predictors of inadequate seizure control within 1 year, and a nomogram was constructed for risk stratification.
Results:
Preoperative GRE was significantly correlated with younger age, male gender, left hemisphere tumor, and a better Karnofsky performance score (p < .05 for all). GRE showed no significant influence on overall survival or progression-free survival (p < .05 for all). Preoperative GRE was identified as the only independent risk factor for postoperative GRE within 1 year after surgery (OR 3.059, 95% CI 1.806-5.183, p < .001).
Conclusions:
The current study offered valuable insights into GRE in patients with oligodendroglioma, IDH-mutant, and 1p/19q-codeleted. Younger age, left hemisphere tumor, and a better Karnofsky performance score were associated with a higher incidence of preoperative GRE. Although preoperative GRE showed no significant prognostic value for survival outcomes, it was the sole independent risk factor for postoperative GRE within 1 year after surgery.
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