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Diagnostic performance of ultrasonography in Crohn's disease: A systematic review and meta-analysis
Yen-Jen Wang1, Yow-Ling Shiue2, I-Ha Lao3
1Department of Medical Imaging, Chi Mei Hospital, Liouying, Tainan.
Aims:
To determine whether ultrasonography (US) provide similar accuracy as ileocolonoscopy, magnetic resonance enterography (MRE), and computed tomography enterography (CTE) in Crohn's disease (CD) diagnosis.
Material And Methods:
In this systematic review and meta-analysis PubMed, EMBASE, and Cochrane CENTRAL were searched from inceptionto December 2024 for studies that evaluated the diagnostic performance of US. Pooled sensitivity, specificity, and hierarchical summary receiver operating characteristic (HSROC) parameters were calculated. Subgroup and sensitivity analyses were performed, and publication bias was assessed with Deeks' funnel plot.
Results:
Nine prospective and 2 retrospective studies were included. The pooled sensitivity and specificity of US for detecting active bowel lesions were 0.86 (95% confidence interval [CI]: 0.65-0.95) and 0.88 (95% CI: 0.69-0.96, respectively). The HSROC model indicated ultrasound had strong overall diagnostic performance, with a diagnostic odds ratio (OR) of 43.85 (95% CI: 9.68-198.53). No evidence of publication bias was detected, and sensitivity analyses confirmed the robustness of the results.
Conclusions:
Ultrasonography demonstrates high diagnostic accuracy for CD and represents a reliable, non-invasive imaging modality. Standardization of protocols and further multicenter validation are warranted to optimize its clinical application.
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