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Related Concept Videos

Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...

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Updated: Jun 3, 2026

Come to the Light Side: In Vivo Monitoring of Pseudomonas aeruginosa Biofilm Infections in Chronic Wounds in a Diabetic Hairless Murine Model
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Published on: October 10, 2017

Artificial Skin Dressing With pH-Switchable Nanozyme Activity for Bidirectional ROS Regulation in Infected Diabetic

Zhe Tang1, Xinyu Zeng1, Jianmin Zhou1

  • 1South China Advanced Institute for Soft Matter Science and Technology, School of Emergent Soft Matter, Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices, Guangdong Basic Research Center of Excellence for Energy and Information Polymer Materials, South China University of Technology, Guangzhou, China.

Small (Weinheim an Der Bergstrasse, Germany)
|June 2, 2026
PubMed
Summary
This summary is machine-generated.

A novel pH-switchable artificial skin dressing, TPI-PADL, effectively manages diabetic infected wounds. It dynamically adjusts its therapeutic actions, coordinating antibacterial, anti-inflammatory, and pro-regenerative effects for improved healing.

Keywords:
ROS modulationantibacterialartificial skin dressingdiabetic wound healingmultifunctional nanozyme

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Creation and Transplantation of an Adipose-derived Stem Cell (ASC) Sheet in a Diabetic Wound-healing Model

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Wound Healing

Background:

  • Diabetic infected wounds exhibit poor healing due to hyperglycemia, microbial colonization, and chronic inflammation.
  • Current treatments often fail to address the complex, dynamic nature of the wound microenvironment.

Purpose of the Study:

  • To develop a smart artificial skin dressing, TPI-PADL, that dynamically adapts to the changing microenvironment of diabetic infected wounds.
  • To integrate therapeutic functions (antibacterial, anti-inflammatory, antioxidant, pro-regenerative) with real-time sensing capabilities.

Main Methods:

  • Development of a pH-switchable dressing incorporating polydopamine and L-arginine modified PtAu nanozymes in a conductive ionogel-fiber scaffold.
  • Nanozymes exhibit dual activity: initial reactive oxygen species (ROS) generation in acidic/hyperglycemic conditions, followed by ROS scavenging and oxygen release at neutral pH.
  • In vitro and in vivo studies to evaluate the dressing's therapeutic efficacy and strain-sensing capability.

Main Results:

  • TPI-PADL effectively kills bacteria and disrupts biofilms in early infection stages by increasing ROS.
  • The dressing shifts to ROS scavenging and oxygen generation, reducing oxidative stress and promoting angiogenesis and pro-healing macrophage phenotypes.
  • The ionogel scaffold provides strain-sensing for real-time monitoring of wound mechanical changes.
  • Integrated therapeutic and sensing functions were confirmed in vitro and in vivo.

Conclusions:

  • The pH-switchable TPI-PADL dressing offers a multi-functional platform for diabetic wound management.
  • This integrated therapy and sensing approach addresses key challenges in diabetic wound healing, including infection, inflammation, and poor regeneration.
  • TPI-PADL demonstrates significant potential for advancing the treatment of chronic diabetic wounds.