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Published on: April 23, 2021
Meta-analysis of Early Risk Factors Associated with Cerebrovascular Diseases.
Sanam Preet Kour1, Himanshu Joshi2, Ratnakar Shukla1
1Department of Clinical Research, Sharda School of Allied Health Sciences, Sharda University, Gautam Buddha Nagar, Uttar Pradesh, Greater Noida, 221310, India.
Current Neurovascular Research
|June 2, 2026
Summary
Early-life factors like high BMI, hypertension, and diabetes significantly increase cerebrovascular disease risk. Preventive strategies starting in childhood are crucial for reducing long-term disease burden.
Area of Science:
- Neurology
- Public Health
- Epidemiology
Background:
- Cerebrovascular diseases, including stroke, affect brain blood vessels and have significant mortality.
- Modifiable and non-modifiable risk factors contribute to disease development.
- Understanding early-life risk factors is crucial for effective prevention.
Purpose of the Study:
- To systematically review and synthesize evidence on early-life risk factors for cerebrovascular diseases.
- To identify statistically proven associations between early-life exposures and cerebrovascular events.
Main Methods:
- Systematic literature search across PubMed, Medline, and Google Scholar for studies on early-life risk factors (childhood to adolescence).
- Screening of articles based on PRISMA guidelines, including various study designs.
- Quality and risk of bias assessment using a custom framework evaluating six domains.
Main Results:
- Strong associations found between male gender, high blood pressure, smoking, high BMI, hypertension, and diabetes with cerebrovascular disease.
- Elevated cholesterol and adverse childhood experiences showed a suggestive increased risk.
- Low physical activity, low birth weight, and low IQ were not conclusively linked.
Conclusions:
- Early-life modifiable factors (high BMI, hypertension, diabetes) significantly elevate cerebrovascular disease risk.
- Preventive strategies targeting these factors from early life are essential.
- Further research may clarify the role of factors like low physical activity and low IQ.
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