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Mendelian Randomization Analysis of Psoriasis and Multiparameter Renal Function Trajectories
1Department of Dermatology, Anhui Medical University, Hefei, Anhui, 230022, China.
Endocrine, Metabolic & Immune Disorders Drug Targets
|June 2, 2026
Summary
This study found no genetic link between psoriasis and kidney disease. Psoriasis does not appear to cause kidney impairment, challenging previous observational findings and suggesting focus on other risk factors.
Area of Science:
- Genetics
- Epidemiology
- Nephrology
Background:
- Observational studies suggest a link between psoriasis and renal impairment, but evidence for causality is inconclusive.
- Psoriasis is an inflammatory condition with potential systemic effects.
- Kidney function encompasses static measures and dynamic progression patterns.
Purpose of the Study:
- To investigate the genetic causality between psoriasis and multidimensional renal function trajectories using Mendelian randomization.
- To assess the impact of genetic liability to psoriasis on various kidney outcomes.
- To differentiate genetic effects from confounding factors in the psoriasis-kidney relationship.
Main Methods:
- Utilized a two-sample Mendelian randomization (MR) framework with genetic variants for psoriasis from a large genome-wide study.
- Examined six kidney outcomes: estimated glomerular filtration rate (eGFR), albuminuria, chronic kidney disease (CKD G3-G5), dialysis, accelerated CKD progression (CKDi25), and rapid renal function deterioration (Rapid3).
- Applied MR-PRESSO for outlier correction and inverse-variance weighted (IVW) analyses with comprehensive sensitivity analyses.
Main Results:
- No significant causal association was found between genetic liability to psoriasis and any of the assessed renal outcomes (eGFR, albuminuria, CKD G3-G5, dialysis, CKDi25, Rapid3).
- Statistical analyses (P-values > 0.05) indicated no evidence of psoriasis causally influencing kidney function or its progression.
- No evidence of horizontal pleiotropy was detected, strengthening the validity of the MR findings.
Conclusions:
- The study provides robust genetic evidence that psoriasis itself does not causally impact kidney function.
- Observed associations in prior studies may be confounded by factors like drug use, comorbidities, or surveillance bias.
- Clinical screening for kidney disease should prioritize traditional risk factors (hypertension, diabetes) over psoriasis as a direct causal driver.
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