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Updated: Jun 3, 2026
Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells
Published on: December 27, 2017
[Clinical Significance of CCRL2 Regulating Platelet Function in Pediatric Chronic Immune Thrombocytopenia]
Fei Yang1,2, Qi Wang3, Yang Li3
1Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases, NHC Key Laboratory of Thrombosis and Hemostasis, The First Affiliated Hospital of Soochow University, Suzhou 215000, Jiangsu Province, China.
Insights
Platelet C-C motif chemokine receptor-like 2 (CCRL2) expression is decreased in children with chronic immune thrombocytopenia (ITP), potentially explaining weakened platelet function. Deleting CCRL2 impaired platelet aggregation and adhesion.
Area of Science:
- Hematology
- Immunology
- Platelet Biology
Objective:
To investigate the expression of C-C motif chemokine receptor-like 2 (CCRL2) on platelets in children with chronic primary immune thrombocytopenia(ITP), and its effect on platelet function.
Methods:
11 chronic ITP patients who were diagnosed at the Department of Hematology of Children's Hospital of Soochow University from April 2023 to September 2024, and 12 control cases were enrolled in this study. Both the expression of CCRL2 on platelets was measured, and the effects of Ccrl2 deletion on platelet production and function were evaluated.
Results:
Deletion of Ccrl2 did not affect platelet counts and megakaryopoiesis, but significantly impaired the maximum aggregation rate, P-selectin expression, and adhesive ability to collagen I of platelets. In addition, the levels of CCRL2 and CD36 on platelets in children with chronic ITP were significantly decreased. However, the absolute number of neutrophils and the concentrations of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) and Defensin Alpha 1(DEFA1) were significantly increased.
Conclusion:
The weakened platelet function in children with chronic ITP may be related to the decreased CCRL2 expression.
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